PUBLICATIONS

生殖細胞グループ

2026年

• Nakayama K, Hayashi Y. ヒト遺伝性疾患モデルとしてのキイロショウジョウバエ. 遺伝子医学. 2026 Jully 25; 16(2) 113-119.

• Kawaguchi A, Igari M, Murayama Y, Iikawa H, Sakamoto M, Nakamura Y, Kuraku S, Ishihara K, Saito D. ATAC-seq of low-input and cryopreserved primordial germ cells reveals functional enhancers. Development. 2026 May 1;153(9):dev205214.

• Morita M, Morimoto M, Ikenouchi J, Pain B, Atsuta Y, Hayashi Y, Teramoto T, Saito D. Bleb-based extravasation uses conserved morphodynamics but divergent calcium control. Nat Commun. 2026 Mar 26.

• Hayashi Y, Doi A, Iikawa H, Kimijima H, Suzuki Y, Kanai A, Hirakawa H, Saito D. Transcriptome Comparison Between the Cultured and In Vivo Chick Primordial Germ Cells by SMART-Seq-Based Single-Cell RNA Sequencing. Dev Growth Differ. 2026 Apr;68(3):e70049.

2025年

• Hayashi Y, Hino S, Sato T, Kashio S, Otsubo K, Saito K, Sato B, Kawano N, Saito D, Miura M, Suyama M, Nakao M, Kobayashi S. Repressive S-adenosylmethionine biosynthesis status inhibits transcription of HeT-A retrotransposon in the germline of Drosophila. J Biochem. 2025 Sep 30;178(4):217-228.

• Morimoto M, Saito D. Avian primordial germ cell migration: History, mechanisms, applications, and unanswered questions. Protein Expr Purif. 2025 Nov;235:106788.

• Morita M, Fujii R, Ryuno A, Morimoto M, Inoko A, Inoue T, Ikenouchi J, Atsuta Y, Hayashi Y, Teramoto T, Saito D. The yolk sac vasculature in early avian embryo provides a novel model for the analysis of cancer extravasation. Dev Biol. 2025 May 15;524:162-175.

• Hayashi Y, Sato B, Kageyama R, Miyado K, Saito D, Kobayashi S, Kawano N. Comprehensive observation of histone lysine lactylation during gametogenesis of Drosophila melanogaster. Dev Dyn. 2025 Mar 28.

• Masakazu, N., & Yoshiki, H. (2025). メチオニン代謝による組織老化制御. Journal of Japanese Biochemical Society, 97(2), 225–230.

2024年

• Iikawa H, Nishina A, Morita M, Atsuta Y, Hayashi Y, Saito D. Labeling and sorting of avian primordial germ cells utilizing Lycopersicon Esculentum lectin. Dev Growth Differ. 2024 Dec;66(9):452-461.

• Nakato E, Kamimura K, Knudsen C, Masutani S, Takemura M, Hayashi Y, Akiyama T, Nakato H. Differential heparan sulfate dependency of the Drosophila glypicans. J Biol Chem. 2024 Jan;300(1):105544.

2023年

• Chen YC, Saito D, Suzuki T, Takemoto T. An inducible germ cell ablation chicken model for high-grade germline chimeras. Development. 2023 Sep 15;150(18):dev202079.

2022年

• Saito D, Tadokoro R, Nagasaka A, Yoshino D, Teramoto T, Mizumoto K, Funamoto K, Kidokoro H, Miyata T, Tamura K, Takahashi Y. Stiffness of primordial germ cells is required for their extravasation in avian embryos. iScience. 2022 Nov 18;25(12):105629.

2021年

• Murai, H, Shibuya, M, Kishita, R, Sunase, C, Tamura, K, Saito, D. Envelopment by endothelial cells initiates translocation of avian primordial germ cell into vascular tissue. Developmental Dynamics. 2021; 250: 1410– 1419.
• Yamanaka, S. Murai, H. Saito, D. Abe, G. Tokunaga, E. Iwasaki, T. Takahashi, H. Takeda, H. Suzuki, T. Shibata, N. Tamura, K. and Sawasaki, T.: Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF. EMBO J. e2020105375, 2021

2018年

• Egawa, S., Saito, D., Abe, G. and Tamura, K.: Morphogenetic mechanism of the acquisition of the dinosaur-type acetabulum. R. Soc. Open Sci. 5: 180604, 2018
• Yoshino, T. and Saito, D.: Epithelial-to-mesenchymal transition-based morphogenesis of dorsal mesentery and gonad. Semin. Cell Dev.Biol. S1084-9521(17)30548-7, 2018

2017年

• Seki, R., Li, C., Fang, Q., Hayashi, S., Egawa, S., Hu, J., Xu, L., Pan, H., Kondo, M., Sato, T., Matsubara, H., Kamiyama, N., Kitajima, K., Saito, D., Liu, Y., Gilbert, M.T.P., Zhou, Q., Xu, X., Shiroishi, T., Irie, N., Tamura, K., and Zhang, G.: Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features. Nat. Commun. 8: 14229, 2017
• Matsubara, H., Saito, D., Abe, G., Yokoyama, H., Suzuki T., and Tamura, K.: Upstream regulation for initiation of restricted Shh expression in the chick limb bud. Dev. Dyn. 246: 417-430, 2017
• Saito, D., Tamura, K. and Takahashi, Y.: Early segregation of the adrenal cortex and gonad in chicken embryos. Dev. Growth Differ. 59: 593-602, 2017

2016年

• Yoshino, T., Murai, H. and Saito, D.: Hedgehog–BMP signaling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos. Nat. Commun. 7: 12561, 2016

2015年

• Takahashi, T., Takase, Y., Yoshino, T., Saito, D., Tadokoro, R. and Takahashi, Y.: Angiogenesis in the developing spinal cord: Blood vessel exclusion from neural progenitor region is mediated by VEGF and its Antagonists. PLoS One 10: e0116119, 2015
• Seki, R., Kitajima, K., Matsubara, H., Suzuki, T., Saito, D., Yokoyama, H. and Tamura, K.: AP-2β is a transcriptional regulator for determination of digit length in tetrapods. Dev. Biol. 407: 75-89, 2015

2014年

• Yoshino, T., Saito, D., Atsuta, Y., Uchiyama, C., Ueda, S., Sekiguchi, K. and Takahashi, Y.: Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet. Proc. Natl. Acad. Sci. USA 111: 6660-6665, 2014

2012年

• Saito, D., Takase, Y., Murai, H. and Takahashi, Y.: The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification. Science, 336: 1578-1581, 2012

2011年

• Yoshino, T., Saito, D., Tadokoro, R. and Takahashi, Y.: In vivo gene manipulations of epithelial cell sheets: a novel model to study epithelial-to-mesenchymal transition. Dev. Growth Differ. 53: 378-388, 2011
• Yokota, Y., Saito, D., Tadokoro, R. and Takahashi, Y.: Genomically integrated transgenes are stably and conditionally expressed in neural crest cell-specific lineages. Dev. Biol. 353: 382-395, 2011

2009年

• Watanabe, T., Sato, Y., Saito, D., Tadokoro, R. and Takahashi, Y.: EphrinB2 cordinates the formation of a morphological boundary and cell epithelialization during somite segmentation. Proc. Natl. Acad. Sci. USA 106: 7467-7472, 2009
• Ohata, E., Tadokoro, R., Sato, Y., Saito, D. and Takahashi, Y.: Notch signal is sufficient to direct an endothelial conversion from non-endothelial somitic cells conveyed to the aortic region by CXCR4. Dev. Biol. 335: 33-42, 2009

2008年

• Sato, Y., Watanabe, T., Saito, D., Takahashi, T., Yoshida, S., Kohyama, J., Ohata,, E., Okano, H. and Takahashi, Y.: Notch signaling mediates the segmental specification of angioblasts in somites and their directed migration toward the dorsal aorta in avian embryos. Dev. Cell 14: 890-901, 2008

2007年

• Watanabe, T., Saito, D., Tanabe, K., Suetsugu, R., Nakaya, Y., Nakagawa, S. and Takahashi, Y.: Tet-on inducible system combined with in ovo electroporation dissects multiple roles of genes in somitogenesis of chicken embryos. Dev. Biol. 305: 625-636, 2007

2006年

• Saito, D., Yonei-Tamura, S., Takahashi, Y. and Tamura, K.: Level-specific role of paraxial mesoderm in regulation of Tbx5/Tbx4 expression and limb initiation. Dev. Biol. 292: 79-89, 2006

2003年

• Tamura, K., Amano, T., Sato, T., Saito, D., Yonei-Tamura, S. and Yajima, H.: Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud. Mechanism of Development 120: 199-209, 2003

2002年

• Saito, D., Yonei-Tamura, S., Kano, K., Ide, H. and Tamura, K.: Specification and determination of limb identity: evidence for inhibitory regulation of Tbx gene expression. Development 129: 211-220, 2002

形態グループ

2026年

• Kwon SJ, Zou Z, Watanabe S, Honda M, Oki S, Atsuta Y. PIC-RNA-seq for Region-Specific Transcriptomic Analysis of Chicken Limb Bud Progenitors. Bio-protocol 2026 Sep 22; 16(20) e5843.

• Kwon SJ, Zou Z, Honda M, Egawa S, Oki S, Atsuta Y. Heterochronic activation of TGF-β signaling drives the diversity of the avian sterna. Nat Commun. 2026 Apr 29.

2025年

• Kuriyama S, Shigematsu K, Kwon SJ, Kuwata R, Atsuta Y. Optimization of Culture and Transfection Methods for Primary Snake Cells. Dev Growth Differ. 2025 Jun 9. (published ahead online)

• Atsuta Y, Chen YC, Hattori Y, Takemoto T, Saito D. Generation of a transgenic chicken line with reporters for limb bud mesenchyme and apical ectodermal ridge cells. Dev Biol. 2025 Jan 8;520:53-61.

2024年

• Atsuta Y, Lee C, Rodrigues AR, Colle C, Tomizawa RR, Lujan EG, Tschopp P, Galan L, Zhu M, Gorham JM, Vannier JP, Seidman CE, Seidman JG, Ros MA, Pourquié O, Tabin CJ. Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors. Dev Cell. 2024 Feb 5;59(3):415-430.e8.

2023年

• Suzuki K, Kwon SJ, Saito D, Atsuta Y. LIN28 is essential for the maintenance of chicken primordial germ cells. Cells Dev. 2023 Jul 14;176:203874.

2022年

• Atsuta, Y., Suzuki, K., Iikawa, H., Yaguchi, H., & Saito, D. (2022). Prime editing in chicken fibroblasts and primordial germ cells. Development, Growth & Differentiation, 1– 10.
• Tomizawa RR, Tabin CJ, Atsuta Y. In ovo electroporation of chicken limb bud ectoderm: Electroporation to chick limb ectoderm: Electroporation to chick limb ectoderm. Dev Dyn. 2022 Sep;251(9):1628-1638.

2021年

• Aldea D, Atsuta Y, Kokalari B, Schaffner SF, Prasasya RD, Aharoni A, Dingwall HL, Warder B, Kamberov YG. Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2021722118.

2019年

• Atsuta Y, Tomizawa RR, Levin M, Tabin CJ. L-type voltage-gated Ca²⁺ channel Ca_V1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21592-21601.

2016年

• Atsuta Y, Takahashi Y. Early formation of the Müllerian duct is regulated by sequential actions of BMP/Pax2 and FGF/Lim1 signaling. Development. 2016 Oct 1;143(19):3549-3559.

2015年

• Atsuta Y, Takahashi Y. FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis. Development. 2015 Jul 1;142(13):2329-37.

2013年

• Atsuta, Y., Tadokoro, R., Saito, D. and Takahashi, Y.: Transgenesis of the Wolffian duct visualizes dynamic behavior of cells undergoing tubulogenesis in vivo. Dev. Growth Differ. 55: 579-590, 2013