https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/dgd.12948?msockid=1ce4ec97281861662359ff9c29af603b<\/a><\/p>\n\n\n\n\u672c\u8ad6\u6587\u306b\u3064\u3044\u3066<\/p>\n\n\n\n
\u9ce5\u985e\u306f\u4e00\u90e8\u306e\u6050\u7adc\u304b\u3089\u6d3e\u751f\u3057\u3066\u9032\u5316\u3057\u305f\u7cfb\u7d71\u7fa4\u3067\u3042\u308a\u3001\u7d04\u4e00\u4e07\u7a2e\u304c\u73fe\u5b58\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u591a\u304f\u306e\u9ce5\u985e\u7a2e\u306f\u5546\u696d\u7684\u306a\u4fa1\u5024\u304c\u9ad8\u304f\u3001\u98df\u6599\u3068\u3057\u3066\u3060\u3051\u3067\u306a\u304f\u3001\u7fbd\u6bdb\u7b49\u306e\u6750\u6599\u8cc7\u6e90\u3068\u3057\u3066\u3001\u611b\u73a9\u52d5\u7269\u3068\u3057\u3066\u3001\u3055\u3089\u306b\u306f\u7814\u7a76\u306b\u7528\u3044\u308b\u305f\u3081\u306e\u5b66\u8853\u7684\u8cc7\u6e90\u3068\u3057\u3066\u5e45\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u4eba\u985e\u306e\u7523\u696d\u6d3b\u52d5\u306e\u5f71\u97ff\u3082\u3042\u308a\u300117\u4e16\u7d00\u4ee5\u964d\u3001\u77e5\u3089\u308c\u3066\u3044\u308b\u3060\u3051\u3067\u3082\u7d04130\u7a2e\u306e\u9ce5\u985e\u304c\u7d76\u6ec5\u3057\u3001\u4eca\u3082\u591a\u304f\u306e\u7a2e\u304c\u305d\u306e\u5371\u6a5f\u306b\u7015\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n
\u9ce5\u985e\u7a2e\u3092\u4fdd\u5b58\u3059\u308b\u305f\u3081\u306b\u3001\u6211\u3005\u306f\u4f55\u304c\u51fa\u6765\u308b\u3067\u3057\u3087\u3046\u304b\u3002\u3082\u3061\u308d\u3093\u3001\u74b0\u5883\u3092\u6539\u5584\u3057\u3001\u9ce5\u985e\u306e\u4e71\u7372\u3092\u7981\u6b62\u3059\u308b\u3053\u3068\u306f\u3001\u6211\u3005\u4eba\u985e\u306e\u7fa9\u52d9\u3067\u3042\u308a\u307e\u3059\u304c\u3001\u3088\u308a\u76f4\u63a5\u7684\u306a\u89e3\u6c7a\u7b56\u3068\u3057\u3066\u3001\u7cbe\u5b50\u3084\u5375\u3068\u3044\u3063\u305f\u6210\u719f\u3057\u305f\u751f\u6b96\u7d30\u80de\u3092\u51cd\u7d50\u4fdd\u5b58\u3057\u3001\u4eba\u5de5\u6388\u7cbe\u7b49\u306e\u6280\u8853\u306b\u3088\u3063\u3066\u500b\u4f53\u3092\u518d\u73fe\u3059\u308b\u3068\u3044\u3046\u65b9\u6cd5\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u9ce5\u985e\u3067\u306f\u3001\u7cbe\u5b50\u306e\u307f\u3001\u3057\u304b\u3082\u4e00\u90e8\u306e\u9ce5\u985e\u306b\u9650\u308a\u305d\u306e\u51cd\u7d50\u4fdd\u5b58\u304c\u53ef\u80fd\u306a\u72b6\u6cc1\u3067\u3059\u3002\u5375\u306f\u7279\u306b\u5375\u9ec4\u304c\u5927\u304d\u3044\u305f\u3081\u3001\u51cd\u7d50\u306e\u969b\u306b\u6c37\u306e\u7d50\u6676\u304c\u751f\u3058\u3001\u7d30\u80de\u3092\u50b7\u3064\u3051\u3066\u3057\u307e\u3046\u305f\u3081\u51cd\u7d50\u4fdd\u5b58\u3067\u304d\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u8fd1\u5e74\u958b\u767a\u3055\u308c\u305f\u65b9\u6cd5\u306f\u3001\u300c\u5375\u3084\u7cbe\u5b50\u306b\u306a\u308b\u4ee5\u524d\u306e\u751f\u6b96\u7d30\u80de\u3001\u59cb\u539f\u751f\u6b96\u7d30\u80de\uff08PGC; Primordial Germ Cell\uff09\u3092\u51cd\u7d50\u4fdd\u5b58\u3059\u308b\u300d\u3068\u3044\u3046\u65b9\u6cd5\u3067\u3059\u3002<\/p>\n\n\n\n
PGC\u306f\u5b75\u5316\u3059\u308b\u524d\u306e\u500b\u4f53\uff08\u80da\uff09\u306e\u6642\u306e\u751f\u6b96\u7d30\u80de\u3067\u3059\u3002PGC\u306f14\u03bcm\u7a0b\u5ea6\u306e\u300c\u666e\u901a\u300d\u306e\u7d30\u80de\u3067\u3042\u308a(\u4e00\u822c\u7684\u306a\u7d30\u80de\u3088\u308a\u3082\u591a\u5c11\u5927\u304d\u3044\u3067\u3059\u304c)\u3001\u5375\u9ec4\u3092\u542b\u307e\u306a\u3044\u305f\u3081\u3001\u7c21\u5358\u306b\u51cd\u7d50\u304c\u53ef\u80fd\u3067\u3059\u3002PGC\u306e\u51cd\u7d50\u306e\u305f\u3081\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
1. \u80da\u306e\u4e2d\u304b\u3089PGC\u3060\u3051\u7279\u7570\u7684\u306b\u30e9\u30d9\u30eb\u3059\u308b\u3002<\/p>\n\n\n\n
2. \u30e9\u30d9\u30eb\u3057\u305fPGC\u3060\u3051\u3092\u6a5f\u68b0\u3067\u5358\u96e2\u3059\u308b\u3002<\/p>\n\n\n\n
3. PGC\u3092\u51cd\u7d50\u4fdd\u5b58\u6db2\u306b\u306a\u3058\u307e\u305b\u3001\u51cd\u7d50\u4fdd\u5b58\u3059\u308b\u3002<\/p>\n\n\n\n
\uff12\u3001\uff13\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u65e2\u306b\u78ba\u7acb\u3055\u308c\u305f\u6280\u8853\u304c\u3042\u308a\u307e\u3059\u304c\u3001\uff11\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u306fPGC\u3060\u3051\u306b\u5b58\u5728\u3059\u308b\u76ee\u5370\u3092\u898b\u3064\u3051\u3001\u305d\u308c\u3092\u7d30\u80de\u304c\u751f\u304d\u305f\u72b6\u614b\u3067\u30e9\u30d9\u30eb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u30c8\u30de\u30c8\u30ec\u30af\u30c1\u30f3\u3068\u3044\u3046\u7cd6\u9396\u3092\u8a8d\u8b58\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u30014\u7a2e\u306e\u9ce5\u985e\uff08\u30cb\u30ef\u30c8\u30ea\u3001\u30a6\u30ba\u30e9\u3001\u30a2\u30d2\u30eb\u3001\u30a8\u30df\u30e5\u30fc\uff09\u306ePGC\u3092\u7c21\u5358\u306b\u30e9\u30d9\u30eb\u3057\u3001\u5358\u96e2\u3059\u308b\u65b9\u6cd5\u3001\u3059\u306a\u308f\u3061\u65b0\u305f\u306a\u300c1\u300d\u306e\u65b9\u6cd5\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u65b9\u6cd5\u306f\u3001\u5f93\u6765\u30cb\u30ef\u30c8\u30eaPGC\u306e\u5358\u96e2\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u305f\u30e9\u30d9\u30eb\u65b9\u6cd5\uff08SSEA-1\u306e\u514d\u75ab\u67d3\u8272\uff09\u3068\u6bd4\u8f03\u3057\u3066\u6975\u3081\u3066\u7c21\u4fbf\u304b\u3064\u5b89\u4fa1\u3067\u3042\u308a\u3001\u304b\u3064SSEA-1\u3088\u308a\u3082\u591a\u304f\u306ePGC\u3092\u30e9\u30d9\u30eb\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u307e\u305f\u3001\u3053\u306e\u30c8\u30de\u30c8\u30ec\u30af\u30c1\u30f3\u30e9\u30d9\u30eb\u6cd5\u306f\u3001\u9ce5\u985e\u3092\u69cb\u6210\u3059\u308b\uff12\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5c5e\u3059\u308b\u7a2e\uff08\u80f8\u5cf0\u985e\u2015\u30ad\u30b8\u30ab\u30e2\u985e\uff1a\u30cb\u30ef\u30c8\u30ea\u3001\u30a6\u30ba\u30e9\u3001\u30a2\u30d2\u30eb\uff1b\u5e73\u80f8\u985e\uff1a\u30a8\u30df\u30e5\u30fc\uff09\u3067\u6709\u52b9\u3067\u3042\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u4ed6\u306e\u9ce5\u985e\u306b\u3082\u9069\u7528\u304c\u5e83\u304c\u308b\u53ef\u80fd\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
\u30c8\u30de\u30c8\u30ec\u30af\u30c1\u30f3\u30e9\u30d9\u30eb\u6cd5\u306b\u3088\u3063\u3066\u3069\u3093\u306a\u9ce5\u985e\u306ePGC\u3082\u67d3\u8272\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u308c\u3070\u3001\u9ce5\u985e\u306e\u4fdd\u5168\u3084\u3001\u7814\u7a76\u3001\u8fb2\u696d\u306b\u5927\u304d\u304f\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u4eca\u5f8c\u3001\u65b0\u9ce5\u985e\uff08\u80f8\u5cf0\u985e\u2015\u65b0\u9ce5\u985e\uff09\u3092\u7528\u3044\u305f\u691c\u8a3c\u3092\u884c\u3046\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30c8\u30de\u30c8\u30ec\u30af\u30c1\u30f3\u30e9\u30d9\u30eb\u6cd5\u304c\u9ce5\u985e\u5168\u822c\u306b\u9069\u7528\u53ef\u80fd\u3067\u3042\u308b\u304b\u3092\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
\u6982\u8981 \u9ce5\u985e\u306f\u4eba\u9593\u793e\u4f1a\u306b\u5fc5\u8981\u4e0d\u53ef\u6b20\u306a\u8cc7\u6e90\u3067\u3059\u304c\u3001\u305d\u308c\u3089\u306e\u4fdd\u5168\u3068\u8cc7\u6e90\u5229\u7528\u306f\u59cb\u539f\u751f\u6b96\u7d30\u80de\uff08PGC\uff09\u306b\u6df1\u304f\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u751f\u304d\u305fPGC\u3092\u80da\u304b\u3089\u5358\u96e2\u3059\u308b\u305f\u3081\u306e\u52b9\u679c\u7684\u306a\u65b9\u6cd5\u306f\u30cb\u30ef\u30c8\u30ea\u306b\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u73fe\u5b58\u306e\u65b9\u6cd5\u3067\u3082\u5206\u53d6\u52b9\u7387…<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4,12],"tags":[],"class_list":["post-989","post","type-post","status-publish","format-standard","hentry","category-events","category-academic-paper"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/posts\/989","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/comments?post=989"}],"version-history":[{"count":1,"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/posts\/989\/revisions"}],"predecessor-version":[{"id":990,"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/posts\/989\/revisions\/990"}],"wp:attachment":[{"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/media?parent=989"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/categories?post=989"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biology.kyushu-u.ac.jp\/~animaldevelopment\/index.php\/wp-json\/wp\/v2\/tags?post=989"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}