九州大学大学院

生体高分子学研究室

Protein Science and Cellular Biochemistry

発表論文

[2017年]
  • Maki, K., Shibata, T., and *Kawabata, S. (2017). Transglutaminase-catalyzed Incorporation of Polyamines Masks the DNA-binding Region of the Transcription Factor Relish. J. Biol. Chem., in press.
[2016年]
  • Sekihara, S., Shibata, T., Hyakkendani, M., and *Kawabata, S. (2016). RNA interference directed against the Transglutaminase gene triggers dysbiosis of gut microbiota in Drosophila. J. Biol. Chem., 291, 25077-25087.
[2015年]
  • *Koshiba, T. (2015). Protein-protein interactions of mitochondrial-associated protein via bioluminescence resonance energy transfer. Biophysics and Physicobiology, 12, 31-35.
  • Shibata, T., Maki, K., Hadano, J., Fujikawa, T., Kitazaki, K., Koshiba, T., and *Kawabata, S. (2015). Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins. PLOS Pathog., 11, e1005244.
  • Kobayashi, Y., Takahashi, T., Shibata, T., Ikeda, S., Koshiba, T., Mizumura, H., Oda, T., and *Kawabata, S. (2015). Factor B is the second lipopolysaccharide-binding protease zymogen in the horseshoe crab coagulation cascade. J. Biol. Chem., 290, 19379-19386.
  • 吉住拓馬、*小柴琢己. (2015). A型インフルエンザウイルスタンパク質PB1-F2とミトコンドリアとの相互作用解析. 生化学, 87, 144-148. (Review)
  • *小柴琢己. (2015). 抗ウイルス自然免疫におけるミトコンドリアの役割. 細胞工学, 34, 571-575. (Review)
[2014年]
  • Yoshizumi, T., Ichinohe, T., Sasaki, O., Otera, H., Kawabata, S., Mihara, K., and *Koshiba, T. (2014). Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity. Nat. Commun., 5, 4713.
  • Nguyen, T.T., Oh, S.S., Weaver, D., Lewandowska, A., Maxfield, D., Schuler, M.H., Smith, N.K., Macfarlane, J., Saunders, G., Palmer, C.A., Debattisti, V., Koshiba, T., Pulst, S., Feldman, E.L., Hajnoczky, G., and Shaw, J.M. (2014). Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease. Proc. Natl. Acad. Sci. USA, 111, E3631-E3640.
  • Kobayashi, Y., Shiga, T., Shibata, T., Sako, M., Maenaka, K., Koshiba, T., Mizumura, H., Oda, T., and *Kawabata, S. (2014). The N-terminal Arg residue is essential for autocatalytic activation of a lipopolysaccharide-responsive protease zymogen. J. Biol. Chem., 289, 25987-25995.
[2013年]
  • Shibata, T., Sekihara, S., Fujikawa, T., Miyaji, R., Maki, K., Ishihara, T., Koshiba, T., and *Kawabata, S. (2013). Transglutaminase-catalyzed protein-protein crosslinking suppresses the activity of the NF-κB-like transcription factor Relish. Sci. Signal., 6, ra61.
  • Sasaki, O., Yoshizumi, T., Kuboyama, M., Ishihara, T., Suzuki, E., Kawabata, S., and *Koshiba, T. (2013). A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer. Biochim. Biophys. Acta - Mol. Cell Res., 1833, 1017-1027.
  • Ichinohe, T., Yamazaki, T., Koshiba, T., and Yanagi, Y. (2013). Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. Proc. Natl. Acad. Sci. USA, 110, 17963-17968.
  • Onoue, K., Jofuku, A., Ban-Ishihara, R., Ishihara, T., Maeda, M., Koshiba, T., Itoh, T., Fukuda, M., Otera, H., Oka, T., Takano, H., Mizushima, N., Mihara, K., and Ishihara, N. (2013). Fis1 acts as mitochondrial recruitment factor for TBC1D15 that involved in regulation of mitochondrial morphology. J. Cell Sci., 126, 176-185.
  • *Koshiba, T. (2013). Mitochondrial-mediated antiviral immunity. Biochim. Biophys. Acta - Mol. Cell Res., 1833, 225-232. (Review)
  • *小柴琢己. (2013). ミトコンドリアと抗ウイルス免疫. 生化学, 85, 336-344. (Review)
[2012年]
  • Tagawa, K., Yoshihara, T., Shibata, T., Kitazaki, K., Endo, Y., Fujita, T., Koshiba, T., and *Kawabata, S. (2012). Microbe-specific C3b deposition in the horseshoe crab complement system in a C2/factor B-dependent or -independent manner. PLOS ONE, 7, e36783.
[2011年]
  • *Koshiba, T., Yasukawa, K., Yanagi, Y., and Kawabata, S. (2011). Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling. Sci. Signaling, 4, ra7.
  • Koshiba, T., Holman, H. A., Kubara, K., Yasukawa, K., Kawabata, S., Okamoto, K., Macfarlane, J., and Shaw, J. M. (2011). Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: Implications for mitochondrial inheritance. J. Biol. Chem., 286, 354-362.
[2010年]
  • *Kawabata, S., and Muta, T. (2010) Sadaaki Iwanaga: discovery of the lipopolysaccharide- and b-1,3-D-glucan-mediated proteolytic cascade and unique proteins in invertebrate immunity. J. Biochem., 147, 611-618.
  • Cerenius, L., Kawabata, S., Lee, B. L., Nonaka, M., and Soderhall, K. (2010) Proteolytic cascades and their involvement in invertebrate immunity. Trends Biochem. Sci., 35, 575-583.
  • *Kawabata, S. (2010) Immunocompetent molecules and their response network in horseshoe crabs. Invertebrate Immunity, 122-136.
  • Shibata, T., Ariki, S., Shinzawa, N., Miyaji, R., Suyama, H., Sako, M., Inomata, N., Koshiba, T., Kanuka, H., and *Kawabata, S. (2010). Protein crosslinking by Transglutaminase controls cuticle morphogenesis in Drosophila. PLOS ONE, 5, e13477.
  • *小柴琢己. (2010). ミトコンドリア外膜上でのウイルス免疫制御機構. 生化学, 82, 135-139. (Review)
  • *小柴琢己. (2010). ミトコンドリア外膜タンパク質Mitofusin 2によるウイルス免疫制御機構. 実験医学, 28, 429-432. (Review)
[2009年]
  • Yasukawa, K., Oshiumi, H., Takeda, M., Ishihara, N., Yanagi, Y., Seya, T., Kawabata, S., and *Koshiba, T. (2009). Mitofusin 2 inhibits mitochondrial antiviral signaling. Sci. Signaling, 2, ra47.
  • Ueda, Y., Ohwada, S., Abe, Y., Shibata, T., Iijima, M., Yoshimitsu, Y., Koshiba, T., Nakata, M., Ueda, T., and *Kawabata, S. (2009). Factor G utilizes a carbohydrate-binding cleft that is conserved between horseshoe crab and bacteria for the recognition of b-1,3-D-glucans. J. Immunol., 183, 3810-3818.
  • *Kawabata, S., Koshiba, T., and Shibata, T. (2009). The lipopolysaccharide-activated innate immune response network of the horseshoe crab. Invertebrate Survival J., 6, 59-77.
[2008年]
  • Ariki, S., Takahara, S., Fukuoka, T., Ozaki, A., Shibata, T., Endo, Y., Fujita, T., Koshiba, T., and *Kawabata, S. (2008). Factor C acts as a lipopolysaccharide-responsive C3 convertase in horseshoe crab complement activation. J. Immunol., 181, 7994-8001.
  • Kouno, T., Fujitani, N., Mizuguchi, M., Osaki, T., Nishimura, S., Kawabata, S., Aizawa, T., Demura, M., Nitta, K., and Kawano, K. (2008). A novel beta-defensin structure: a potential strategy of big defensin to overcame resistance by Gram-positive bacteria. Biochemistry, 47, 10611-10619.
[2007年]
  • Matsuda, Y., Koshiba, T., Osaki, T., Suyama, H., Arisaka, F., Toh, Y., and *Kawabata, S. (2007). An arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh. J. Biol. Chem., 282, 37316-37324.
  • Matsuda, Y., Osaki, T., Hashii, T., Koshiba, T., and *Kawabata, S. (2007). A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites. J. Biol. Chem., 282, 33545-33552.
  • Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S., Kimura, M., and Shimohigashi, Y. (2007). Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRg. J. Biochem., 142, 517-524.
  • Fujitani, F., Kouno, T., Nakahara, T., Takaya, K., Osaki, T., Kawabata, S., Mizuguchi, M., Aizawa, T., Demura, M., Nishimura, S., and Kawano, K. (2007). The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif. J. Pept. Sci., 13, 269-279.
  • Koshiba, T., Hashii, T., and *Kawabata, S. (2007). A structural perspective on the interaction between lipopolysaccharide and Factor C, a receptor involved in recognition of Gram-negative bacteria. J. Biol. Chem., 282, 3962-3967.
[2006年]
  • Friedrich, R., Panizzi, P., Kawabata, S., Bode, W., Bock, P. E., and Fuentes-Prior, P. (2006). Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation. J. Biol. Chem., 281, 1188-1195.
  • Kurata, S., Ariki, S., and *Kawabata, S. (2006). Recognition of pathogens and activation of immune responses in Drosophila and horseshoe crab innate immunity. Immunobiology, 211, 237-249. (Review)
[2005年]
  • Iijima, M., Hashimoto, T., Matsuda, Y., Nagai, T., Yamano, Y., Ichi, T., Osaki, T. and *Kawabata, S. (2005). Comprehensive sequence analysis of horseshoe crab cuticular proteins and their involvement in transglutaminase-dependent cross-linking. FEBS J., 272, 4774-4786.
  • Ozaki, A., Ariki, S., and *Kawabata, S. (2005). An antimicrobial peptide tachyplesin acts as a secondary secretagogue and amplifies lipopolysaccharide-induced hemocyte exocytosis. FEBS J., 272, 3863-3871.
  • Nakao, M., Maki, K., Arai, M., Koshiba, T., Nitta, K. and Kuwajima, K. (2005). Characterization of kinetic folding intermediates of recombinantcanine milk lysozyme by stopped-flow circular dichroism. Biochemistry, 44, 6685-6692.
  • Honjo, E., Tamada, T., Maeda, Y., Koshiba, T., Matsukura, Y., Okamoto, T., Ishibashi, M., Tokunaga, M., and Kuroki, R. (2005). Crystallization of a 2:2 complex of granulocyte-colony stimulating factor (GCSF) with the ligand-binding region of the GCSF receptor. Acta Cryst., F61, 788-790.
  • *小柴琢己. (2005). ミトコンドリアに見る、生体膜融合機構. 生物物理, 45, 243-246. (Review)
[2004年]
  • Ariki, S., Koori, K., Osaki, T., Motoyama, K., Inamori, K., and *Kawabata, S. (2004). A serine protease zymogen functions as a pattern-recognition receptor for lipopolysaccharides. Proc. Natl. Acad. Sci. USA, 101, 953-958.
  • Koshiba, T., Detmer, S.A., Kaiser, J.T., Chen, H., McCaffery, J.M., and Chan, D. C. (2004). Structural basis of mitochondrial tethering by mitofusin complexes. Science, 305, 858-862.
  • Mine, S., Koshiba, T., Honjo, E, Okamoto, T., Tamada, T., Maeda, Y.,Matsukura, Y., Horie, A., Ishibashi, M., Sato, M., Azuma, M., Tokunaga, M.,Nitta, K., and Kuroki, R. (2004). Thermodynamic analysis of the activationmechanism of the GCSF receptor induced by ligand binding. Biochemistry, 43, 2458-2464.
  • Osaki, T., and *Kawabata, S. (2004). Structure and function of coagulogen, a clottable protein in horseshoe crabs. Cell. Mol. Life Sci., 61, 1257-1265. (Review)
  • Inamori, K., Ariki, S., and *Kawabata, S. (2004). A Toll-like receptor in horseshoe crabs. Immunol. Rev., 198, 106-115. (Review)
  • *小柴琢己, David C. Chan. (2004). Mitofusinを介したミトコンドリアの融合機構. 細胞工学, 23, 1174-1175. (Review)
  • *川畑俊一郎. (2004). 自然免疫における糖鎖認識の分子基盤. 生化学, 76, 201-206. (Review)
[2003年]
  • Koshiba, T., and Chan, D. C. (2003). The prefusogenic intermediate of HIV-1 gp41 contains exposed C-peptide regions. J. Biol. Chem., 278, 7573-7579.
  • Nakao, M., Arai, M., Koshiba, T., Nitta, K., and Kuwajima, K. (2003). Folding mechanism of canine milk lysozyme studied by circular dichroism and fluorescence spectroscopy. Spectroscopy, 17, 183-193.
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